Assay Detail
Functional
CHEMBL5577193
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human LoVo cells harboring wild-type EGFR assessed as reduction in cell growth incubated for 72 hrs by CCK8 assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LoVo |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploring the structural activity relationship of the Osimertinib: A covalent inhibitor of double mutant EGFR<sup>L858R/T790M</sup> tyrosine kinase for the treatment of Non-Small Cell Lung Cancer (NSCLC).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.54 | 6.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3353404 | — | — | 1 | 6.84 |
| CHEMBL3353405 | — | — | 1 | 6.03 |
| CHEMBL3353396 | — | — | 1 | 5.80 |
| CHEMBL3353403 | — | — | 1 | 5.47 |
| CHEMBL3353399 | — | — | 1 | 5.12 |
| CHEMBL3353402 | — | — | 1 | 5.05 |
| CHEMBL3353395 | — | — | 1 | 5.00 |
| CHEMBL3353400 | — | — | 1 | 4.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3353404 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL3353405 | — | IC50 | = | 938.0 | nM | 6.03 |
| CHEMBL3353396 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3353403 | — | IC50 | = | 3357.0 | nM | 5.47 |
| CHEMBL3353399 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL3353402 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3353395 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3353400 | — | IC50 | = | 10300.0 | nM | 4.99 |