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Assay Detail

CHEMBL5577685

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human ALK6 using casein as substrate in presence of [gamma-33P]ATP and 10 uM ATP by radiometric assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Bone morphogenetic protein receptor type-1B (CHEMBL5476)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2.
Němec V, Remeš M, Beňovský P, Böck MC, Šranková E, Wong JF, Cros J, Williams E, Tse LH, Smil D, Ensan D, Isaac MB, Al-Awar R, Gomolková R, Ursachi VC, Fafílek B, Kahounová Z, Víchová R, Vacek O, Berger BT, Wells CI, Corona CR, Vasta JD, Robers MB, Krejci P, Souček K, Bullock AN, Knapp S, Paruch K.
J Med Chem (2024) 67 : 12632 -12659
PubMed 39023313 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 34 6.43 7.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5590317 1 7.82
CHEMBL5083143 1 7.39
CHEMBL4548795 1 7.06
CHEMBL5595157 1 6.91
CHEMBL5591254 1 6.28
CHEMBL5594050 1 6.27
CHEMBL5593513 1 6.27
CHEMBL5590255 1 5.99
CHEMBL5592705 1 5.95
CHEMBL5592206 1 5.95
CHEMBL5592629 1 5.94
CHEMBL5595818 1 5.91
CHEMBL5594766 1 5.86
CHEMBL5583693 1 -
CHEMBL5593258 1 -
CHEMBL5589853 1 -
CHEMBL5590714 1 -
CHEMBL5592288 1 -
CHEMBL5593369 1 -
CHEMBL5591957 1 -
CHEMBL5591016 1 -
CHEMBL5595814 1 -
CHEMBL5590219 1 -
CHEMBL5579725 1 -
CHEMBL5595923 1 -
CHEMBL5591557 1 -
CHEMBL5595161 1 -
CHEMBL5583679 1 -
CHEMBL5595002 1 -
CHEMBL5590609 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5590317 IC50 = 15.0 nM 7.82
CHEMBL5083143 IC50 = 41.0 nM 7.39
CHEMBL4548795 IC50 = 88.0 nM 7.06
CHEMBL5595157 IC50 = 123.0 nM 6.91
CHEMBL5591254 IC50 = 524.0 nM 6.28
CHEMBL5594050 IC50 = 536.0 nM 6.27
CHEMBL5593513 IC50 = 532.0 nM 6.27
CHEMBL5590255 IC50 = 1013.0 nM 5.99
CHEMBL5592705 IC50 = 1112.0 nM 5.95
CHEMBL5592206 IC50 = 1120.0 nM 5.95
CHEMBL5592629 IC50 = 1150.0 nM 5.94
CHEMBL5595818 IC50 = 1220.0 nM 5.91
CHEMBL5594766 IC50 = 1380.0 nM 5.86
CHEMBL5594471 IC50 > 3000.0 nM -
CHEMBL5594501 IC50 > 3000.0 nM -
CHEMBL5595327 IC50 > 3000.0 nM -
CHEMBL5593123 IC50 > 3000.0 nM -
CHEMBL5583693 IC50 > 3000.0 nM -
CHEMBL5593258 IC50 > 3000.0 nM -
CHEMBL5589853 IC50 > 3000.0 nM -
CHEMBL5590714 IC50 > 3000.0 nM -
CHEMBL5592288 IC50 > 3000.0 nM -
CHEMBL5593369 IC50 > 3000.0 nM -
CHEMBL5591957 IC50 > 3000.0 nM -
CHEMBL5591016 IC50 > 3000.0 nM -
CHEMBL5595814 IC50 > 3000.0 nM -
CHEMBL5590219 IC50 > 3000.0 nM -
CHEMBL5579725 IC50 > 3000.0 nM -
CHEMBL5595923 IC50 > 3000.0 nM -
CHEMBL5591557 IC50 > 3000.0 nM -
CHEMBL5595161 IC50 > 3000.0 nM -
CHEMBL5583679 IC50 > 3000.0 nM -
CHEMBL5595002 IC50 > 3000.0 nM -
CHEMBL5590609 IC50 > 3000.0 nM -