Assay Detail
Binding
CHEMBL5577692
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human KHS using myelin basic protein as substrate in presence of [gamma-33P]ATP and 10 uM ATP by radiometric assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase kinase 5 (CHEMBL4852) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.27 | 6.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5083143 | — | — | 1 | 6.27 |
| CHEMBL4548795 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5083143 | — | IC50 | = | 539.0 | nM | 6.27 |
| CHEMBL4548795 | — | IC50 | - | — | - |