Assay Detail
Functional
CHEMBL5578036
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cell proliferation in human KLE cells incubated for 48 hrs by CCK-8 assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KLE |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Azaphenothiazine Derivatives to Suppress Endometrial Cancer by Targeting GRP75 to Impair Its Interaction with IP3R and Mitochondrial Ca<sup>2+</sup> Homeostasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.16 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5595115 | — | — | 1 | 5.54 |
| CHEMBL5583884 | — | — | 1 | 5.50 |
| CHEMBL5592860 | — | — | 1 | 5.50 |
| CHEMBL5594405 | — | — | 1 | 5.46 |
| CHEMBL5591081 | — | — | 1 | 5.45 |
| CHEMBL5591987 | — | — | 1 | 5.40 |
| CHEMBL5583814 | — | — | 1 | 5.21 |
| CHEMBL5595504 | — | — | 1 | 5.09 |
| CHEMBL5591231 | — | — | 1 | 5.08 |
| CHEMBL5593982 | — | — | 1 | 5.07 |
| CHEMBL5590735 | — | — | 1 | 5.02 |
| CHEMBL5591062 | — | — | 1 | 5.00 |
| CHEMBL5595359 | — | — | 1 | 4.99 |
| CHEMBL5590484 | — | — | 1 | 4.97 |
| CHEMBL5590128 | — | — | 1 | 4.84 |
| CHEMBL1713 | CHLORPROMAZINE HYDROCHLORIDE | 4.0 | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5595115 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL5583884 | — | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL5592860 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL5594405 | — | IC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL5591081 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL5591987 | — | IC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL5583814 | — | IC50 | = | 6230.0 | nM | 5.21 |
| CHEMBL5595504 | — | IC50 | = | 8060.0 | nM | 5.09 |
| CHEMBL5591231 | — | IC50 | = | 8310.0 | nM | 5.08 |
| CHEMBL5593982 | — | IC50 | = | 8520.0 | nM | 5.07 |
| CHEMBL5590735 | — | IC50 | = | 9550.0 | nM | 5.02 |
| CHEMBL5591062 | — | IC50 | = | 9990.0 | nM | 5.00 |
| CHEMBL5595359 | — | IC50 | = | 10320.0 | nM | 4.99 |
| CHEMBL5590484 | — | IC50 | = | 10740.0 | nM | 4.97 |
| CHEMBL5590128 | — | IC50 | = | 14450.0 | nM | 4.84 |
| CHEMBL1713 | CHLORPROMAZINE HYDROCHLORIDE | IC50 | = | 35010.0 | nM | 4.46 |