Assay Detail
Functional
CHEMBL5578105
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at DRD2 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Azaphenothiazine Derivatives to Suppress Endometrial Cancer by Targeting GRP75 to Impair Its Interaction with IP3R and Mitochondrial Ca<sup>2+</sup> Homeostasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.06 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL243712 | AMISULPRIDE | 4.0 | 1 | 7.89 |
| CHEMBL1713 | CHLORPROMAZINE HYDROCHLORIDE | 4.0 | 1 | 7.75 |
| CHEMBL5595359 | — | — | 1 | 5.55 |
| CHEMBL5592860 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL243712 | AMISULPRIDE | IC50 | = | 12.98 | nM | 7.89 |
| CHEMBL1713 | CHLORPROMAZINE HYDROCHLORIDE | IC50 | = | 17.98 | nM | 7.75 |
| CHEMBL5595359 | — | IC50 | = | 2786.0 | nM | 5.55 |
| CHEMBL5592860 | — | IC50 | > | 10000.0 | nM | - |