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Assay Detail

CHEMBL5578423

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Escherichia coli NEU2 using 4-MUNANA as substrate preincubated with compound for 0.25 hrs followed by substrate addition and measured after 0.5 hrs by fluorescence based analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Bioisosteres at C9 of 2-Deoxy-2,3-didehydro-<i>N</i>-acetyl Neuraminic Acid Identify Selective Inhibitors of NEU3.
Radwan M, Guo T, Carvajal EG, Bekkema BAR, Cairo CW.
J Med Chem (2024) 67 : 13594 -13603
PubMed 39101748 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.14 4.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4076203 1 4.22
CHEMBL96712 NEU5AC2EN 1 4.16
CHEMBL5590354 1 4.05
CHEMBL5594004 1 -
CHEMBL5591566 1 -
CHEMBL5583781 1 -
CHEMBL5594290 1 -
CHEMBL4294428 1 -
CHEMBL4285561 1 -
CHEMBL5590360 1 -
CHEMBL5590001 1 -
CHEMBL5591326 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4076203 IC50 = 60000.0 nM 4.22
CHEMBL96712 NEU5AC2EN IC50 = 70000.0 nM 4.16
CHEMBL5590354 IC50 = 90000.0 nM 4.05
CHEMBL5594004 IC50 > 500000.0 nM -
CHEMBL5591566 IC50 > 500000.0 nM -
CHEMBL5583781 IC50 > 500000.0 nM -
CHEMBL5594290 IC50 > 500000.0 nM -
CHEMBL4294428 IC50 > 500000.0 nM -
CHEMBL4285561 IC50 > 500000.0 nM -
CHEMBL5590360 IC50 = 350000.0 nM -
CHEMBL5590001 IC50 > 500000.0 nM -
CHEMBL5591326 IC50 > 500000.0 nM -