Assay Detail
Binding
CHEMBL5578801
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged human recombinant OGA using fuoresceinmono-beta-o-N-acetylglucosarnine as substrate incubated for 60 mins under dark condition by microplate reader based analysis
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 4-(Arylethynyl)piperidine Derivatives as Potent Nonsaccharide <i>O</i>-GlcNAcase Inhibitors for the Treatment of Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 62 | 7.72 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5591488 | — | — | 1 | 9.47 |
| CHEMBL5591695 | — | — | 1 | 9.37 |
| CHEMBL5593700 | — | — | 1 | 9.14 |
| CHEMBL5594475 | — | — | 1 | 9.07 |
| CHEMBL5591879 | — | — | 1 | 8.81 |
| CHEMBL5592778 | — | — | 1 | 8.76 |
| CHEMBL5594221 | — | — | 1 | 8.74 |
| CHEMBL5592978 | — | — | 1 | 8.67 |
| CHEMBL5590780 | — | — | 1 | 8.52 |
| CHEMBL5593511 | — | — | 1 | 8.49 |
| CHEMBL5579695 | — | — | 1 | 8.46 |
| CHEMBL5592385 | — | — | 1 | 8.44 |
| CHEMBL5591089 | — | — | 1 | 8.43 |
| CHEMBL5591704 | — | — | 1 | 8.36 |
| CHEMBL5591551 | — | — | 1 | 8.33 |
| CHEMBL5591513 | — | — | 1 | 8.31 |
| CHEMBL5583946 | — | — | 1 | 8.26 |
| CHEMBL5591099 | — | — | 1 | 8.10 |
| CHEMBL5591460 | — | — | 1 | 8.06 |
| CHEMBL5595991 | — | — | 1 | 8.06 |
| CHEMBL5591200 | — | — | 1 | 8.05 |
| CHEMBL5584048 | — | — | 1 | 8.05 |
| CHEMBL5590193 | — | — | 1 | 8.02 |
| CHEMBL5591950 | — | — | 1 | 7.99 |
| CHEMBL5594139 | — | — | 1 | 7.97 |
| CHEMBL5592023 | — | — | 1 | 7.92 |
| CHEMBL5592284 | — | — | 1 | 7.80 |
| CHEMBL5595937 | — | — | 1 | 7.79 |
| CHEMBL5592814 | — | — | 1 | 7.71 |
| CHEMBL5593028 | — | — | 1 | 7.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5591488 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL5591695 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL5593700 | — | IC50 | = | 0.72 | nM | 9.14 |
| CHEMBL5594475 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL5591879 | — | IC50 | = | 1.54 | nM | 8.81 |
| CHEMBL5592778 | — | IC50 | = | 1.73 | nM | 8.76 |
| CHEMBL5594221 | — | IC50 | = | 1.82 | nM | 8.74 |
| CHEMBL5592978 | — | IC50 | = | 2.13 | nM | 8.67 |
| CHEMBL5590780 | — | IC50 | = | 3.04 | nM | 8.52 |
| CHEMBL5593511 | — | IC50 | = | 3.25 | nM | 8.49 |
| CHEMBL5579695 | — | IC50 | = | 3.49 | nM | 8.46 |
| CHEMBL5592385 | — | IC50 | = | 3.61 | nM | 8.44 |
| CHEMBL5591089 | — | IC50 | = | 3.75 | nM | 8.43 |
| CHEMBL5591704 | — | IC50 | = | 4.36 | nM | 8.36 |
| CHEMBL5591551 | — | IC50 | = | 4.63 | nM | 8.33 |
| CHEMBL5591513 | — | IC50 | = | 4.93 | nM | 8.31 |
| CHEMBL5583946 | — | IC50 | = | 5.44 | nM | 8.26 |
| CHEMBL5591099 | — | IC50 | = | 7.99 | nM | 8.10 |
| CHEMBL5591460 | — | IC50 | = | 8.73 | nM | 8.06 |
| CHEMBL5595991 | — | IC50 | = | 8.76 | nM | 8.06 |
| CHEMBL5591200 | — | IC50 | = | 8.86 | nM | 8.05 |
| CHEMBL5584048 | — | IC50 | = | 8.88 | nM | 8.05 |
| CHEMBL5590193 | — | IC50 | = | 9.53 | nM | 8.02 |
| CHEMBL5591950 | — | IC50 | = | 10.27 | nM | 7.99 |
| CHEMBL5594139 | — | IC50 | = | 10.77 | nM | 7.97 |
| CHEMBL5592023 | — | IC50 | = | 12.16 | nM | 7.92 |
| CHEMBL5592284 | — | IC50 | = | 15.74 | nM | 7.80 |
| CHEMBL5595937 | — | IC50 | = | 16.04 | nM | 7.79 |
| CHEMBL5592814 | — | IC50 | = | 19.41 | nM | 7.71 |
| CHEMBL5593028 | — | IC50 | = | 22.52 | nM | 7.65 |
| CHEMBL5591919 | — | IC50 | = | 23.61 | nM | 7.63 |
| CHEMBL5592529 | — | IC50 | = | 23.89 | nM | 7.62 |
| CHEMBL5593505 | — | IC50 | = | 25.05 | nM | 7.60 |
| CHEMBL5590863 | — | IC50 | = | 25.88 | nM | 7.59 |
| CHEMBL5595069 | — | IC50 | = | 29.11 | nM | 7.54 |
| CHEMBL5590741 | — | IC50 | = | 32.34 | nM | 7.49 |
| CHEMBL5591556 | — | IC50 | = | 33.04 | nM | 7.48 |
| CHEMBL5584000 | — | IC50 | = | 33.76 | nM | 7.47 |
| CHEMBL5594381 | — | IC50 | = | 41.98 | nM | 7.38 |
| CHEMBL5594264 | — | IC50 | = | 42.68 | nM | 7.37 |
| CHEMBL5590996 | — | IC50 | = | 42.29 | nM | 7.37 |
| CHEMBL5593786 | — | IC50 | = | 43.29 | nM | 7.36 |
| CHEMBL5591471 | — | IC50 | = | 49.15 | nM | 7.31 |
| CHEMBL5591664 | — | IC50 | = | 51.41 | nM | 7.29 |
| CHEMBL5583610 | — | IC50 | = | 51.98 | nM | 7.28 |
| CHEMBL5596027 | — | IC50 | = | 53.63 | nM | 7.27 |
| CHEMBL5583633 | — | IC50 | = | 56.85 | nM | 7.25 |
| CHEMBL5594901 | — | IC50 | = | 57.38 | nM | 7.24 |
| CHEMBL5593996 | — | IC50 | = | 58.41 | nM | 7.23 |
| CHEMBL5592062 | — | IC50 | = | 62.52 | nM | 7.20 |