Assay Detail
Binding
CHEMBL5578845
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to SHP2 (unknown origin) by SPR analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 11 (CHEMBL3864) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of JAB-3312, a Potent SHP2 Allosteric Inhibitor for Cancer Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 19 | 8.59 | 9.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5595838 | — | — | 1 | 9.43 |
| CHEMBL5591410 | — | — | 1 | 9.38 |
| CHEMBL4752051 | — | — | 1 | 9.28 |
| CHEMBL4752599 | — | — | 1 | 9.04 |
| CHEMBL5583655 | — | — | 1 | 8.92 |
| CHEMBL5591213 | — | — | 1 | 8.92 |
| CHEMBL4789817 | — | — | 1 | 8.89 |
| CHEMBL5591400 | — | — | 1 | 8.80 |
| CHEMBL5591249 | — | — | 1 | 8.80 |
| CHEMBL5595416 | — | — | 1 | 8.70 |
| CHEMBL4745425 | — | — | 1 | 8.47 |
| CHEMBL5595486 | — | — | 1 | 8.43 |
| CHEMBL5593594 | — | — | 1 | 8.40 |
| CHEMBL5592824 | — | — | 1 | 8.24 |
| CHEMBL4784611 | — | — | 1 | 8.14 |
| CHEMBL4761760 | — | — | 1 | 8.06 |
| CHEMBL4060033 | — | — | 1 | 8.00 |
| CHEMBL5596036 | — | — | 1 | 7.80 |
| CHEMBL4752704 | — | — | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5595838 | — | Kd | = | 0.37 | nM | 9.43 |
| CHEMBL5591410 | — | Kd | = | 0.42 | nM | 9.38 |
| CHEMBL4752051 | — | Kd | = | 0.53 | nM | 9.28 |
| CHEMBL4752599 | — | Kd | = | 0.92 | nM | 9.04 |
| CHEMBL5583655 | — | Kd | = | 1.2 | nM | 8.92 |
| CHEMBL5591213 | — | Kd | = | 1.2 | nM | 8.92 |
| CHEMBL4789817 | — | Kd | = | 1.3 | nM | 8.89 |
| CHEMBL5591400 | — | Kd | = | 1.6 | nM | 8.80 |
| CHEMBL5591249 | — | Kd | = | 1.6 | nM | 8.80 |
| CHEMBL5595416 | — | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL4745425 | — | Kd | = | 3.4 | nM | 8.47 |
| CHEMBL5595486 | — | Kd | = | 3.7 | nM | 8.43 |
| CHEMBL5593594 | — | Kd | = | 4.0 | nM | 8.40 |
| CHEMBL5592824 | — | Kd | = | 5.8 | nM | 8.24 |
| CHEMBL4784611 | — | Kd | = | 7.3 | nM | 8.14 |
| CHEMBL4761760 | — | Kd | = | 8.8 | nM | 8.06 |
| CHEMBL4060033 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL5596036 | — | Kd | = | 16.0 | nM | 7.80 |
| CHEMBL4752704 | — | Kd | = | 26.0 | nM | 7.58 |