Assay Detail
Toxicity
CHEMBL5578846
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Inhibition of human ERG by manual patch clamp method
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of JAB-3312, a Potent SHP2 Allosteric Inhibitor for Cancer Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.31 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5591473 | — | — | 1 | 6.40 |
| CHEMBL4789817 | — | — | 1 | 5.82 |
| CHEMBL5595295 | — | — | 1 | 5.75 |
| CHEMBL5593317 | — | — | 1 | 5.72 |
| CHEMBL5583655 | — | — | 1 | 5.70 |
| CHEMBL5591410 | — | — | 1 | 5.70 |
| CHEMBL5591249 | — | — | 1 | 5.52 |
| CHEMBL5591213 | — | — | 1 | 5.52 |
| CHEMBL5595838 | — | — | 1 | 5.36 |
| CHEMBL5595416 | — | — | 1 | 5.16 |
| CHEMBL4752051 | — | — | 1 | 5.09 |
| CHEMBL5591400 | — | — | 1 | 5.01 |
| CHEMBL5590142 | — | — | 1 | 4.99 |
| CHEMBL4752599 | — | — | 1 | 4.93 |
| CHEMBL5583724 | — | — | 1 | 4.88 |
| CHEMBL5594924 | — | — | 1 | 4.80 |
| CHEMBL4745425 | — | — | 1 | 4.78 |
| CHEMBL5583696 | — | — | 1 | 4.52 |
| CHEMBL5583758 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5591473 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4789817 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5595295 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5593317 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5583655 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5591410 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5591249 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5591213 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5595838 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL5595416 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4752051 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL5591400 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL5590142 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4752599 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL5583724 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL5594924 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL4745425 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL5583696 | — | IC50 | = | 29900.0 | nM | 4.52 |
| CHEMBL5583758 | — | IC50 | > | 30000.0 | nM | - |