Assay Detail
Binding
CHEMBL5578848
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Inhibition of ERK phosphorylation in human KYSE520 cells incubated for 2 hrs by HTRF method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | KYSE520 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of JAB-3312, a Potent SHP2 Allosteric Inhibitor for Cancer Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.79 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4752051 | — | — | 1 | 9.60 |
| CHEMBL5591213 | — | — | 1 | 9.40 |
| CHEMBL4745425 | — | — | 1 | 9.36 |
| CHEMBL4789817 | — | — | 1 | 9.01 |
| CHEMBL5591400 | — | — | 1 | 9.01 |
| CHEMBL4752599 | — | — | 1 | 8.85 |
| CHEMBL5591410 | — | — | 1 | 8.62 |
| CHEMBL5595416 | — | — | 1 | 8.59 |
| CHEMBL4752704 | — | — | 1 | 7.77 |
| CHEMBL5595838 | — | — | 1 | 7.64 |
| CHEMBL5583655 | — | — | 1 | - |
| CHEMBL5591249 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4752051 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL5591213 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4745425 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL4789817 | — | IC50 | = | 0.98 | nM | 9.01 |
| CHEMBL5591400 | — | IC50 | = | 0.98 | nM | 9.01 |
| CHEMBL4752599 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5591410 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5595416 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4752704 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5595838 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5583655 | — | IC50 | - | — | - | |
| CHEMBL5591249 | — | IC50 | - | — | - |