Assay Detail
Functional
CHEMBL5578897
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Invivo inhibition of ERK phosphorylation in po dosed NOD/SCID mouse tumor xenografted with human KYSE-520 cells measured upto 24 hrs by HTRF method
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of JAB-3312, a Potent SHP2 Allosteric Inhibitor for Cancer Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 7.71 | 7.71 |
| EC90 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4752051 | — | — | 2 | 7.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4752051 | — | EC50 | = | 19.6 | nM | 7.71 |
| CHEMBL4752051 | — | EC90 | = | 276.0 | nM | - |