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Assay Detail

CHEMBL5579018

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human A549 cells incubated for 24 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A549
Confidence 1 — Organism
Curated By Autocuration

Target

A549 (CHEMBL392)
Type CELL-LINE
Organism Homo sapiens

Publication

Computational Design of Pore-Forming Peptides with Potent Antimicrobial and Anticancer Activities.
Deb R, Torres MDT, Boudný M, Koběrská M, Cappiello F, Popper M, Dvořáková Bendová K, Drabinová M, Hanáčková A, Jeannot K, Petřík M, Mangoni ML, Balíková Novotná G, Mráz M, de la Fuente-Nunez C, Vácha R.
J Med Chem (2024) 67 : 14040 -14061
PubMed 39116273 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 4 4.77 5.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5584167 1 5.00
CHEMBL5590247 1 4.75
CHEMBL5593337 1 4.75
CHEMBL5594579 1 4.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5584167 IC50 = 10000.0 nM 5.00
CHEMBL5590247 IC50 = 18000.0 nM 4.75
CHEMBL5593337 IC50 = 18000.0 nM 4.75
CHEMBL5594579 IC50 = 26000.0 nM 4.58