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Assay Detail

CHEMBL5579294

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Functional
Antiplasmodial activity against asexual Plasmodium falciparum 3D7 incubated for 72 hrs by LDH assay
ChEMBL ↗
61
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364) ↗
Type ORGANISM
Organism Plasmodium falciparum

Publication

Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4.
Ashton TD, Calic PPS, Dans MG, Ooi ZK, Zhou Q, Palandri J, Loi K, Jarman KE, Qiu D, Lehane AM, Maity BC, De N, Giannangelo C, MacRaild CA, Creek DJ, Mao EY, Gancheva MR, Wilson DW, Chowdury M, de Koning-Ward TF, Famodimu MT, Delves MJ, Pollard H, Sutherland CJ, Baud D, Brand S, Jackson PF, Cowman AF, Sleebs BE.
J Med Chem (2024) 67 : 14493 -14523
PubMed 39134060 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 61 7.11 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5595794 — — 1 8.40
CHEMBL5583869 — — 1 8.15
CHEMBL5594154 — — 1 8.10
CHEMBL5407464 — — 1 8.10
CHEMBL5592834 — — 1 8.10
CHEMBL5592756 — — 1 8.00
CHEMBL5429894 — — 1 8.00
CHEMBL5592695 — — 1 7.96
CHEMBL5592130 — — 1 7.85
CHEMBL5436150 — — 1 7.85
CHEMBL5595902 — — 1 7.80
CHEMBL5593596 — — 1 7.80
CHEMBL5584047 — — 1 7.80
CHEMBL5416425 — — 1 7.77
CHEMBL5427940 — — 1 7.72
CHEMBL5591827 — — 1 7.64
CHEMBL5591057 — — 1 7.60
CHEMBL5595345 — — 1 7.52
CHEMBL5590696 — — 1 7.51
CHEMBL5590156 — — 1 7.43
CHEMBL5593217 — — 1 7.43
CHEMBL5590101 — — 1 7.42
CHEMBL5594930 — — 1 7.33
CHEMBL5583549 — — 1 7.32
CHEMBL5593566 — — 1 7.32
CHEMBL5595740 — — 1 7.29
CHEMBL5594200 — — 1 7.21
CHEMBL5584115 — — 1 7.19
CHEMBL5595251 — — 1 7.17
CHEMBL5591562 — — 1 7.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5595794 — EC50 = 4.0 nM 8.40
CHEMBL5583869 — EC50 = 7.0 nM 8.15
CHEMBL5407464 — EC50 = 8.0 nM 8.10
CHEMBL5592834 — EC50 = 8.0 nM 8.10
CHEMBL5594154 — EC50 = 8.0 nM 8.10
CHEMBL5592756 — EC50 = 10.0 nM 8.00
CHEMBL5429894 — EC50 = 10.0 nM 8.00
CHEMBL5592695 — EC50 = 11.0 nM 7.96
CHEMBL5592130 — EC50 = 14.0 nM 7.85
CHEMBL5436150 — EC50 = 14.0 nM 7.85
CHEMBL5595902 — EC50 = 16.0 nM 7.80
CHEMBL5593596 — EC50 = 16.0 nM 7.80
CHEMBL5584047 — EC50 = 16.0 nM 7.80
CHEMBL5416425 — EC50 = 17.0 nM 7.77
CHEMBL5427940 — EC50 = 19.0 nM 7.72
CHEMBL5591827 — EC50 = 23.0 nM 7.64
CHEMBL5591057 — EC50 = 25.0 nM 7.60
CHEMBL5595345 — EC50 = 30.0 nM 7.52
CHEMBL5590696 — EC50 = 31.0 nM 7.51
CHEMBL5590156 — EC50 = 37.0 nM 7.43
CHEMBL5593217 — EC50 = 37.0 nM 7.43
CHEMBL5590101 — EC50 = 38.0 nM 7.42
CHEMBL5594930 — EC50 = 47.0 nM 7.33
CHEMBL5583549 — EC50 = 48.0 nM 7.32
CHEMBL5593566 — EC50 = 48.0 nM 7.32
CHEMBL5595740 — EC50 = 51.0 nM 7.29
CHEMBL5594200 — EC50 = 62.0 nM 7.21
CHEMBL5584115 — EC50 = 64.0 nM 7.19
CHEMBL5595251 — EC50 = 67.0 nM 7.17
CHEMBL5591562 — EC50 = 69.0 nM 7.16
CHEMBL5579745 — EC50 = 82.0 nM 7.09
CHEMBL5592041 — EC50 = 86.0 nM 7.07
CHEMBL5591680 — EC50 = 90.0 nM 7.05
CHEMBL5583998 — EC50 = 115.0 nM 6.94
CHEMBL5593293 — EC50 = 130.0 nM 6.89
CHEMBL5592811 — EC50 = 180.0 nM 6.75
CHEMBL5591833 — EC50 = 177.0 nM 6.75
CHEMBL5593134 — EC50 = 230.0 nM 6.64
CHEMBL5409773 — EC50 = 230.0 nM 6.64
CHEMBL5583852 — EC50 = 243.0 nM 6.61
CHEMBL5592741 — EC50 = 395.0 nM 6.40
CHEMBL5591693 — EC50 = 430.0 nM 6.37
CHEMBL5590644 — EC50 = 502.0 nM 6.30
CHEMBL5593597 — EC50 = 510.0 nM 6.29
CHEMBL5591440 — EC50 = 577.0 nM 6.24
CHEMBL5592989 — EC50 = 630.0 nM 6.20
CHEMBL5592803 — EC50 = 632.0 nM 6.20
CHEMBL5592131 — EC50 = 660.0 nM 6.18
CHEMBL5591064 — EC50 = 660.0 nM 6.18
CHEMBL5596015 — EC50 = 822.0 nM 6.08