Assay Detail
Functional
CHEMBL5579302
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against Plasmodium falciparum Dd2 harboring I398F/P990R/D1247Y mutants infected in RBC incubated for 72 hrs by malstat reagent based microplate reader assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | RBC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.60 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5594154 | — | — | 1 | 7.17 |
| CHEMBL5583869 | — | — | 1 | 6.92 |
| CHEMBL5436150 | — | — | 1 | 6.85 |
| CHEMBL5590156 | — | — | 1 | 6.17 |
| CHEMBL5590696 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5594154 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5583869 | — | EC50 | = | 119.0 | nM | 6.92 |
| CHEMBL5436150 | — | EC50 | = | 142.0 | nM | 6.85 |
| CHEMBL5590156 | — | EC50 | = | 672.0 | nM | 6.17 |
| CHEMBL5590696 | — | EC50 | = | 1250.0 | nM | 5.90 |