Assay Detail
Functional
CHEMBL5579304
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against Plasmodium falciparum Dd2 harboring F156L mutant infected in RBC incubated for 72 hrs by malstat reagent based microplate reader assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | RBC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.42 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5594154 | — | — | 1 | 8.05 |
| CHEMBL5583869 | — | — | 1 | 7.96 |
| CHEMBL5436150 | — | — | 1 | 7.60 |
| CHEMBL5590156 | — | — | 1 | 6.99 |
| CHEMBL5590696 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5594154 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5583869 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5436150 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL5590156 | — | EC50 | = | 102.0 | nM | 6.99 |
| CHEMBL5590696 | — | EC50 | = | 332.0 | nM | 6.48 |