Assay Detail
Functional
CHEMBL5579314
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against multidrug resistant Plasmodium falciparum Dd2 infected in RBC incubated for 72 hrs by SYBR staining based fluorometer assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | RBC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.91 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5583869 | — | — | 1 | 8.52 |
| CHEMBL5592130 | — | — | 1 | 8.40 |
| CHEMBL5590156 | — | — | 1 | 7.70 |
| CHEMBL5590696 | — | — | 1 | 7.64 |
| CHEMBL5594930 | — | — | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5583869 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5592130 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5590156 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5590696 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5594930 | — | EC50 | = | 52.0 | nM | 7.28 |