Assay Detail
Functional
CHEMBL5579423
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Antiviral activity against Human parainfluenza virus 3 JS infected in human A549 cells assessed as reduction in viral proliferation incubated for 44 hrs by Hoechst dye based fluorescence analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human respirovirus 3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Potent STT3A/B Inhibitors and Assessment of Their Multipathogen Antiviral Potential and Safety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.43 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5595779 | — | — | 1 | 8.22 |
| CHEMBL5583722 | — | — | 1 | 8.05 |
| CHEMBL5583975 | — | — | 1 | 7.92 |
| CHEMBL5583748 | — | — | 1 | 7.24 |
| CHEMBL5591147 | — | — | 1 | 6.73 |
| CHEMBL1720448 | — | — | 1 | 6.42 |
| CHEMBL5589992 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5595779 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5583722 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5583975 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5583748 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5591147 | — | EC50 | = | 187.0 | nM | 6.73 |
| CHEMBL1720448 | — | EC50 | = | 379.0 | nM | 6.42 |
| CHEMBL5589992 | — | EC50 | - | — | - |