Assay Detail
Functional
CHEMBL5579425
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV-2 infected in human A549 cells assessed as reduction in viral growth incubated for 24 hrs by Nano-Glo reagent based analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Discovery of Potent STT3A/B Inhibitors and Assessment of Their Multipathogen Antiviral Potential and Safety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.38 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5583748 | — | — | 1 | 8.40 |
| CHEMBL5595779 | — | — | 1 | 8.40 |
| CHEMBL5583722 | — | — | 1 | 7.47 |
| CHEMBL5591147 | — | — | 1 | 7.21 |
| CHEMBL5589992 | — | — | 1 | 6.94 |
| CHEMBL1720448 | — | — | 1 | 5.87 |
| CHEMBL5583975 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5583748 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5595779 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL5583722 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5591147 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL5589992 | — | EC50 | = | 116.0 | nM | 6.94 |
| CHEMBL1720448 | — | EC50 | = | 1363.0 | nM | 5.87 |
| CHEMBL5583975 | — | EC50 | - | — | - |