Assay Detail
Binding
CHEMBL5579507
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full-length ADAMTS7 truncated before the C-terminal PLAC domain using FAM-Glu-Ala-Ala-Ala-Arg-Ala-Glu-Ala-Ala-Ala-Lys-TAMRA as substrate measured after 24 hrs by FRET assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
A disintegrin and metalloproteinase with thrombospondin motifs 7 (CHEMBL5724789) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of arylsulfonamides as ADAMTS7 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.02 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5592306 | — | — | 1 | 8.22 |
| CHEMBL5589804 | — | — | 1 | 8.05 |
| CHEMBL5591230 | — | — | 1 | 7.40 |
| CHEMBL5594880 | — | — | 1 | 7.40 |
| CHEMBL5595366 | — | — | 1 | 7.30 |
| CHEMBL5593273 | — | — | 1 | 7.30 |
| CHEMBL5593176 | — | — | 1 | 7.16 |
| CHEMBL5594088 | — | — | 1 | 6.66 |
| CHEMBL5589746 | — | — | 1 | 6.42 |
| CHEMBL5592123 | — | — | 1 | 6.26 |
| CHEMBL5590061 | — | — | 1 | 6.03 |
| CHEMBL5593591 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5592306 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL5589804 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL5591230 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL5594880 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL5595366 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL5593273 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL5593176 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL5594088 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL5589746 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL5592123 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL5590061 | — | Ki | = | 940.0 | nM | 6.03 |
| CHEMBL5593591 | — | Ki | = | 1000.0 | nM | 6.00 |