Assay Detail
Toxicity
CHEMBL5579512
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full-length C-terminal FLAG tagged ADAMTS1 expressed in HEK293T cells using 5,6 fluorescein[FAM]-Ala-Glu-Leu-Gln-Gly-Arg-Pro-Ile-Ser-Ile-Ala-Lyscarboxytetramethylrhodamine as substrate preincubated for 1 hr followed by substrate addition and measured at 1 min interval for 2 hrs by FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
A disintegrin and metalloproteinase with thrombospondin motifs 1 (CHEMBL5133) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of arylsulfonamides as ADAMTS7 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.74 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5592306 | — | — | 1 | 7.52 |
| CHEMBL5589804 | — | — | 1 | 7.16 |
| CHEMBL5593176 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5592306 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL5589804 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL5593176 | — | Ki | = | 2800.0 | nM | 5.55 |