Assay Detail
Toxicity
CHEMBL5579514
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human ADAM17 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated for 3 hrs followed by substrate addition and measured at 15 secs interval for 20 mins by fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3706) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of arylsulfonamides as ADAMTS7 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.33 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5593176 | — | — | 1 | 8.10 |
| CHEMBL5592306 | — | — | 1 | 7.00 |
| CHEMBL5589804 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5593176 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL5592306 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL5589804 | — | Ki | = | 130.0 | nM | 6.89 |