Assay Detail
Binding
CHEMBL5579516
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ADAMTS7 (unknown origin) proteolytic activity assessed as increase in uncleaved LTBP4S-A level using purified FLAG-tagged LTBP4S-A as substrate measured after 24 hrs by Western blot analysis
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
A disintegrin and metalloproteinase with thrombospondin motifs 7 (CHEMBL5724789) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of arylsulfonamides as ADAMTS7 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.22 | 7.22 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5589804 | — | — | 2 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5589804 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5589804 | — | Inhibition | - | % | - |