Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5579538

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human CAL-27 cells incubated for 24 hrs by Alamar blue assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CAL-27
Confidence 1 — Organism
Curated By Autocuration

Target

CAL-27 (CHEMBL1075408)
Type CELL-LINE
Organism Homo sapiens

Publication

Targeted suppression of oral squamous cell carcinoma by pyrimidine-tethered quinoxaline derivatives.
Choithramani A, Das R, Bothra G, Patel Vatsa P, Muthukumar V, Bhuvana BKS, Kapoor S, Moola D, Chowdhury MG, Mandoli A, Shard A.
RSC Med Chem (2024) 15 : 2729 -2744
PubMed 39149105 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 4.82 6.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5590652 1 6.10
CHEMBL5592292 1 4.99
CHEMBL5591575 1 4.89
CHEMBL5591772 1 4.86
CHEMBL5583564 1 4.84
CHEMBL5593864 1 4.82
CHEMBL5594257 1 4.80
CHEMBL5591876 1 4.77
CHEMBL5591965 1 4.73
CHEMBL5594847 1 4.71
CHEMBL5590477 1 4.67
CHEMBL5579786 1 4.60
CHEMBL5592061 1 4.57
CHEMBL5584016 1 4.19
CHEMBL5589679 1 -
CHEMBL5583651 1 -
CHEMBL5593729 1 -
CHEMBL5592864 1 -
CHEMBL5595675 1 -
CHEMBL5592852 1 -
CHEMBL5591384 1 -
CHEMBL5592482 1 -
CHEMBL5590234 1 -
CHEMBL5593228 1 -
CHEMBL5583855 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5590652 IC50 = 790.0 nM 6.10
CHEMBL5592292 IC50 = 10290.0 nM 4.99
CHEMBL5591575 IC50 = 12760.0 nM 4.89
CHEMBL5591772 IC50 = 13690.0 nM 4.86
CHEMBL5583564 IC50 = 14550.0 nM 4.84
CHEMBL5593864 IC50 = 15090.0 nM 4.82
CHEMBL5594257 IC50 = 15950.0 nM 4.80
CHEMBL5591876 IC50 = 17010.0 nM 4.77
CHEMBL5591965 IC50 = 18480.0 nM 4.73
CHEMBL5594847 IC50 = 19710.0 nM 4.71
CHEMBL5590477 IC50 = 21550.0 nM 4.67
CHEMBL5579786 IC50 = 25300.0 nM 4.60
CHEMBL5592061 IC50 = 27200.0 nM 4.57
CHEMBL5584016 IC50 = 64760.0 nM 4.19
CHEMBL5589679 IC50 > 100000.0 nM -
CHEMBL5583651 IC50 > 100000.0 nM -
CHEMBL5593729 IC50 > 100000.0 nM -
CHEMBL5592864 IC50 > 100000.0 nM -
CHEMBL5595675 IC50 > 100000.0 nM -
CHEMBL5592852 IC50 > 100000.0 nM -
CHEMBL5591384 IC50 > 100000.0 nM -
CHEMBL5592482 IC50 > 100000.0 nM -
CHEMBL5590234 IC50 > 100000.0 nM -
CHEMBL5593228 IC50 > 100000.0 nM -
CHEMBL5583855 IC50 > 100000.0 nM -