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Assay Detail

CHEMBL5579579

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimalarial activity against blood stage chloroquine-resistant Plasmodium falciparum Dd2 infected in erythrocytes assessed as reduction in parasitemia incubated for 72 hrs by flow cytometry analysis
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Cell Type Erythrocyte
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

"Seasoning" antimalarial drugs' action: chloroquine bile salts as novel triple-stage antiplasmodial hits.
Silva AT, Oliveira I, Duarte D, Moita D, Prudêncio M, Nogueira F, Ferraz R, Marques EF, Gomes P.
RSC Med Chem (2024) 15 : 2657 -2662
PubMed 39149112 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.53 6.69

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5591405 1 6.69
CHEMBL5595341 1 6.68
CHEMBL5595065 1 6.67
CHEMBL5594620 1 6.67
CHEMBL5595955 1 6.62
CHEMBL58510 CHLOROQUINE PHOSPHATE 4.0 1 6.34
CHEMBL43128 PRIMAQUINE PHOSPHATE 4.0 1 6.33
CHEMBL5583850 1 6.25
CHEMBL5595279 1 -
CHEMBL5583945 1 -
CHEMBL411070 GLYCOCHOLIC ACID 3.0 1 -
CHEMBL1478 LITHOCHOLIC ACID 1 -
CHEMBL406393 DEOXYCHOLIC ACID 4.0 1 -
CHEMBL5595328 1 -
CHEMBL205596 CHOLIC ACID 4.0 1 -
CHEMBL5595858 1 -
CHEMBL5584063 1 -
CHEMBL5591754 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5591405 IC50 = 205.0 nM 6.69
CHEMBL5595341 IC50 = 207.0 nM 6.68
CHEMBL5595065 IC50 = 212.0 nM 6.67
CHEMBL5594620 IC50 = 216.0 nM 6.67
CHEMBL5595955 IC50 = 242.0 nM 6.62
CHEMBL58510 CHLOROQUINE PHOSPHATE IC50 = 453.0 nM 6.34
CHEMBL43128 PRIMAQUINE PHOSPHATE IC50 = 464.0 nM 6.33
CHEMBL5583850 IC50 = 562.0 nM 6.25
CHEMBL5595279 IC50 - -
CHEMBL5583945 IC50 - -
CHEMBL411070 GLYCOCHOLIC ACID IC50 - -
CHEMBL1478 LITHOCHOLIC ACID IC50 - -
CHEMBL406393 DEOXYCHOLIC ACID IC50 - -
CHEMBL5595328 IC50 - -
CHEMBL205596 CHOLIC ACID IC50 - -
CHEMBL5595858 IC50 - -
CHEMBL5584063 IC50 - -
CHEMBL5591754 IC50 - -