Assay Detail
Binding
CHEMBL5580225
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Inhibition of LCK (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one scaffolds as potent Lck inhibitors as anti-cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.45 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189338 | — | — | 1 | 8.46 |
| CHEMBL5594600 | — | — | 1 | 7.97 |
| CHEMBL5583654 | — | — | 1 | 7.94 |
| CHEMBL5595544 | — | — | 1 | 7.54 |
| CHEMBL5595581 | — | — | 1 | 7.41 |
| CHEMBL5595530 | — | — | 1 | 7.40 |
| CHEMBL5595663 | — | — | 1 | 7.38 |
| CHEMBL1970879 | — | — | 1 | 6.83 |
| CHEMBL5593666 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189338 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL5594600 | — | IC50 | = | 10.6 | nM | 7.97 |
| CHEMBL5583654 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL5595544 | — | IC50 | = | 28.6 | nM | 7.54 |
| CHEMBL5595581 | — | IC50 | = | 38.7 | nM | 7.41 |
| CHEMBL5595530 | — | IC50 | = | 39.5 | nM | 7.40 |
| CHEMBL5595663 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1970879 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL5593666 | — | IC50 | = | 779.0 | nM | 6.11 |