Assay Detail
Functional
CHEMBL5580872
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Antiproliferative activity against human SiHa cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SiHa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel Hsp90-Targeting PROTACs: Enhanced synergy with cisplatin in combination therapy of cervical cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.47 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1195136 | SNX 5422 | 2.0 | 1 | 7.85 |
| CHEMBL5595590 | — | — | 1 | 7.52 |
| CHEMBL5591571 | — | — | 1 | 7.40 |
| CHEMBL5590945 | — | — | 1 | 7.30 |
| CHEMBL5593635 | — | — | 1 | 7.16 |
| CHEMBL5592399 | — | — | 1 | 6.85 |
| CHEMBL5591948 | — | — | 1 | 6.77 |
| CHEMBL5592988 | — | — | 1 | 6.72 |
| CHEMBL5593619 | — | — | 1 | 6.64 |
| CHEMBL5592876 | — | — | 1 | 6.62 |
| CHEMBL5583765 | — | — | 1 | 6.51 |
| CHEMBL5591874 | — | — | 1 | 6.37 |
| CHEMBL5595856 | — | — | 1 | 6.34 |
| CHEMBL5592356 | — | — | 1 | 6.25 |
| CHEMBL5589942 | — | — | 1 | 6.18 |
| CHEMBL5594137 | — | — | 1 | 6.12 |
| CHEMBL5595791 | — | — | 1 | 5.28 |
| CHEMBL5594791 | — | — | 1 | 5.26 |
| CHEMBL5591444 | — | — | 1 | 5.14 |
| CHEMBL5594721 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1195136 | SNX 5422 | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5595590 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5591571 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5590945 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5593635 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5592399 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5591948 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5592988 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5593619 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5592876 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5583765 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5591874 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5595856 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5592356 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL5589942 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL5594137 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5595791 | — | IC50 | = | 5270.0 | nM | 5.28 |
| CHEMBL5594791 | — | IC50 | = | 5520.0 | nM | 5.26 |
| CHEMBL5591444 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL5594721 | — | IC50 | = | 9610.0 | nM | 5.02 |