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Assay Detail

CHEMBL5581215

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Escherichia coli beta-glucuronidase using p-nitrophenyl glycoside as substrate assessed as release of p-nitrophenol by spectrometric analysis
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Design and synthesis of 6-C-alkyl-DMDP type nanomolar inhibitors of β-galactosidase and β-glucosidase based on broussonetine S and related derivatives.
Gao FT, Wu QK, Zhang M, Shimadate Y, Qian G, Song YY, Kato A, Li YX, Jia YM, Fleet GWJ, Yu CY.
Eur J Med Chem (2024) 275 : 116570 -116570
PubMed 38878517 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.64 5.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5595101 1 5.60
CHEMBL5595646 1 5.57
CHEMBL5592567 1 5.54
CHEMBL5591053 1 5.48
CHEMBL5592010 1 4.66
CHEMBL5590791 1 4.54
CHEMBL5589982 1 4.54
CHEMBL5592633 1 4.48
CHEMBL5594010 1 4.46
CHEMBL5593532 1 4.41
CHEMBL5592849 1 4.41
CHEMBL5591684 1 4.38
CHEMBL5592931 1 4.34
CHEMBL5595884 1 4.31
CHEMBL5593449 1 4.29
CHEMBL5594749 1 4.27
CHEMBL5594464 1 4.25
CHEMBL5593507 1 4.07

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5595101 IC50 = 2500.0 nM 5.60
CHEMBL5595646 IC50 = 2700.0 nM 5.57
CHEMBL5592567 IC50 = 2900.0 nM 5.54
CHEMBL5591053 IC50 = 3300.0 nM 5.48
CHEMBL5592010 IC50 = 22000.0 nM 4.66
CHEMBL5590791 IC50 = 29000.0 nM 4.54
CHEMBL5589982 IC50 = 29000.0 nM 4.54
CHEMBL5592633 IC50 = 33000.0 nM 4.48
CHEMBL5594010 IC50 = 35000.0 nM 4.46
CHEMBL5593532 IC50 = 39000.0 nM 4.41
CHEMBL5592849 IC50 = 39000.0 nM 4.41
CHEMBL5591684 IC50 = 42000.0 nM 4.38
CHEMBL5592931 IC50 = 46000.0 nM 4.34
CHEMBL5595884 IC50 = 49000.0 nM 4.31
CHEMBL5593449 IC50 = 51000.0 nM 4.29
CHEMBL5594749 IC50 = 54000.0 nM 4.27
CHEMBL5594464 IC50 = 56000.0 nM 4.25
CHEMBL5593507 IC50 = 86000.0 nM 4.07