Assay Detail
Binding
CHEMBL5581706
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-terminal 6His-tagged C-RAF (308 to 648 residues) (unknown origin) extracted from baculovirus infected in Sf21 cells by TR-FRET assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAF proto-oncogene serine/threonine-protein kinase (CHEMBL1906) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
An overview of RAF kinases and their inhibitors (2019-2023).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.43 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4583691 | NAPORAFENIB | 3.0 | 1 | 8.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4583691 | NAPORAFENIB | IC50 | = | 3.7 | nM | 8.43 |