Assay Detail
Binding
CHEMBL5581708
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Inhibition of wild-type B-RAF (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
An overview of RAF kinases and their inhibitors (2019-2023).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.64 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2028663 | DABRAFENIB | 4.0 | 1 | 8.49 |
| CHEMBL4583691 | NAPORAFENIB | 3.0 | 1 | 8.43 |
| CHEMBL5591160 | — | — | 1 | 8.23 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 7.66 |
| CHEMBL5518141 | — | — | 1 | 7.30 |
| CHEMBL5557132 | — | — | 1 | 7.15 |
| CHEMBL3348923 | TOVORAFENIB | 4.0 | 1 | 6.20 |
| CHEMBL5591799 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2028663 | DABRAFENIB | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4583691 | NAPORAFENIB | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL5591160 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5518141 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5557132 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL3348923 | TOVORAFENIB | IC50 | = | 633.0 | nM | 6.20 |
| CHEMBL5591799 | — | IC50 | = | 1.1 | nM | - |