Assay Detail
Binding
CHEMBL5581709
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of B-RAF V600E mutant (unknown origin)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
An overview of RAF kinases and their inhibitors (2019-2023).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.84 | 10.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5591799 | — | — | 1 | 10.18 |
| CHEMBL2028663 | DABRAFENIB | 4.0 | 1 | 9.19 |
| CHEMBL5583891 | — | — | 1 | 8.89 |
| CHEMBL5591160 | — | — | 1 | 8.23 |
| CHEMBL3977543 | BELVARAFENIB | 2.0 | 1 | 8.05 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 7.42 |
| CHEMBL4583691 | NAPORAFENIB | 3.0 | 1 | 7.31 |
| CHEMBL5518141 | — | — | 1 | 7.20 |
| CHEMBL5557132 | — | — | 1 | 7.05 |
| CHEMBL3348923 | TOVORAFENIB | 4.0 | 1 | 7.03 |
| CHEMBL5590473 | — | — | 1 | 5.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5591799 | — | IC50 | = | 0.066 | nM | 10.18 |
| CHEMBL2028663 | DABRAFENIB | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL5583891 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5591160 | — | IC50 | = | 5.89 | nM | 8.23 |
| CHEMBL3977543 | BELVARAFENIB | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4583691 | NAPORAFENIB | IC50 | = | 49.2 | nM | 7.31 |
| CHEMBL5518141 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL5557132 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL3348923 | TOVORAFENIB | IC50 | = | 94.2 | nM | 7.03 |
| CHEMBL5590473 | — | IC50 | = | 1840.0 | nM | 5.74 |