Assay Detail
Binding
CHEMBL5581711
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of RAF1 Y340D (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAF proto-oncogene serine/threonine-protein kinase (CHEMBL1906) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
An overview of RAF kinases and their inhibitors (2019-2023).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.38 | 8.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5591160 | — | — | 1 | 8.45 |
| CHEMBL3348923 | TOVORAFENIB | 4.0 | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5591160 | — | IC50 | = | 3.55 | nM | 8.45 |
| CHEMBL3348923 | TOVORAFENIB | IC50 | = | 495.0 | nM | 6.30 |