Assay Detail

CHEMBL5581718

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of C-RAF SSDD mutant (unknown origin) extracted from baculovirus by TR-FRET assay

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

An overview of RAF kinases and their inhibitors (2019-2023).

Hashem O, Shahin AI, Al Hindawi MA, Fageeri MF, Al-Sbbagh SA, Tarazi H, El-Gamal MI.
Eur J Med Chem (2024) 275 : 116631 -116631
PubMed 38954961 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.07	7.07

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3348923	TOVORAFENIB	4.0	1	7.07

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3348923	TOVORAFENIB	IC50	=	84.5	nM	7.07