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Assay Detail

CHEMBL5581842

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human Melmet 5 cells assessed as reduction in cell viability incubated for 72 hrs by CelltiterGlo luminescent assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type Melmet 5
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Promising anti-proliferative indolic benzenesulfonamides alter mechanisms with sulfonamide nitrogen substituents.
Fuentes-Martín R, Ayuda-Durán P, Hanes R, Gallego-Yerga L, Wolterinck L, Enserink JM, Álvarez R, Peláez R.
Eur J Med Chem (2024) 275 : 116617 -116617
PubMed 38959729 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 8.26 10.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL553025 VINORELBINE 4.0 1 10.00
CHEMBL90555 VINCRISTINE 4.0 1 9.70
CHEMBL5589801 1 8.85
CHEMBL428647 PACLITAXEL 4.0 1 8.85
CHEMBL5594274 1 8.80
CHEMBL5591933 1 8.41
CHEMBL5593374 1 8.05
CHEMBL92 DOCETAXEL ANHYDROUS 4.0 1 8.02
CHEMBL5583620 1 7.97
CHEMBL5594310 1 7.91
CHEMBL5593031 1 7.90
CHEMBL5589943 1 7.89
CHEMBL5593749 1 7.79
CHEMBL5591012 1 7.53
CHEMBL5595105 1 7.49
CHEMBL5595113 1 7.02

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL553025 VINORELBINE IC50 = 0.1 nM 10.00
CHEMBL90555 VINCRISTINE IC50 = 0.2 nM 9.70
CHEMBL5589801 IC50 = 1.4 nM 8.85
CHEMBL428647 PACLITAXEL IC50 = 1.4 nM 8.85
CHEMBL5594274 IC50 = 1.6 nM 8.80
CHEMBL5591933 IC50 = 3.9 nM 8.41
CHEMBL5593374 IC50 = 8.9 nM 8.05
CHEMBL92 DOCETAXEL ANHYDROUS IC50 = 9.5 nM 8.02
CHEMBL5583620 IC50 = 10.6 nM 7.97
CHEMBL5594310 IC50 = 12.2 nM 7.91
CHEMBL5593031 IC50 = 12.5 nM 7.90
CHEMBL5589943 IC50 = 12.9 nM 7.89
CHEMBL5593749 IC50 = 16.2 nM 7.79
CHEMBL5591012 IC50 = 29.5 nM 7.53
CHEMBL5595105 IC50 = 32.3 nM 7.49
CHEMBL5595113 IC50 = 96.2 nM 7.02