Assay Detail
Functional
CHEMBL5581845
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Antiproliferative activity against human CAKI-1 cells assessed as reduction in cell viability incubated for 72 hrs by CelltiterGlo luminescent assay
16
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CAKI-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Promising anti-proliferative indolic benzenesulfonamides alter mechanisms with sulfonamide nitrogen substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.80 | 9.52 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 9.52 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 9.05 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 8.57 |
| CHEMBL5589801 | — | — | 1 | 8.40 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 8.24 |
| CHEMBL5589943 | — | — | 1 | 7.96 |
| CHEMBL5591933 | — | — | 1 | 7.89 |
| CHEMBL5594310 | — | — | 1 | 7.53 |
| CHEMBL5595105 | — | — | 1 | 7.53 |
| CHEMBL5594274 | — | — | 1 | 7.49 |
| CHEMBL5593374 | — | — | 1 | 7.25 |
| CHEMBL5593031 | — | — | 1 | 7.18 |
| CHEMBL5593749 | — | — | 1 | 7.01 |
| CHEMBL5595113 | — | — | 1 | 6.80 |
| CHEMBL5591012 | — | — | 1 | 6.51 |
| CHEMBL5583620 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553025 | VINORELBINE | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL5589801 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL5589943 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5591933 | — | IC50 | = | 12.9 | nM | 7.89 |
| CHEMBL5594310 | — | IC50 | = | 29.6 | nM | 7.53 |
| CHEMBL5595105 | — | IC50 | = | 29.5 | nM | 7.53 |
| CHEMBL5594274 | — | IC50 | = | 32.4 | nM | 7.49 |
| CHEMBL5593374 | — | IC50 | = | 56.2 | nM | 7.25 |
| CHEMBL5593031 | — | IC50 | = | 66.2 | nM | 7.18 |
| CHEMBL5593749 | — | IC50 | = | 98.3 | nM | 7.01 |
| CHEMBL5595113 | — | IC50 | = | 158.5 | nM | 6.80 |
| CHEMBL5591012 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5583620 | — | Activity | - | — | - |