Assay Detail
Toxicity
CHEMBL5581848
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Antiproliferative activity against human RPE-1 cells assessed as reduction in cell viability incubated for 72 hrs by CelltiterGlo luminescent assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | TERT-RPE1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Promising anti-proliferative indolic benzenesulfonamides alter mechanisms with sulfonamide nitrogen substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.59 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.29 |
| CHEMBL5589801 | — | — | 1 | 8.24 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 8.12 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 8.09 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.03 |
| CHEMBL5591933 | — | — | 1 | 7.92 |
| CHEMBL5583620 | — | — | 1 | 7.88 |
| CHEMBL5589943 | — | — | 1 | 7.70 |
| CHEMBL5594310 | — | — | 1 | 7.64 |
| CHEMBL5593749 | — | — | 1 | 7.48 |
| CHEMBL5593031 | — | — | 1 | 7.38 |
| CHEMBL5594274 | — | — | 1 | 7.28 |
| CHEMBL5595105 | — | — | 1 | 7.12 |
| CHEMBL5593374 | — | — | 1 | 7.09 |
| CHEMBL5591012 | — | — | 1 | 6.76 |
| CHEMBL5595113 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL5589801 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL5591933 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5583620 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL5589943 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5594310 | — | IC50 | = | 22.7 | nM | 7.64 |
| CHEMBL5593749 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5593031 | — | IC50 | = | 41.3 | nM | 7.38 |
| CHEMBL5594274 | — | IC50 | = | 52.8 | nM | 7.28 |
| CHEMBL5595105 | — | IC50 | = | 76.3 | nM | 7.12 |
| CHEMBL5593374 | — | IC50 | = | 80.4 | nM | 7.09 |
| CHEMBL5591012 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL5595113 | — | IC50 | = | 334.7 | nM | 6.47 |