Assay Detail
Functional
CHEMBL5581853
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Antiproliferative activity against human paclitaxel-resistant MDA-MB-468 cells assessed as inhibition of cell growth incubated for 72 hrs by CelltiterGlo luminescent assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Paclitaxel-resistant MDA-MB-468 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Promising anti-proliferative indolic benzenesulfonamides alter mechanisms with sulfonamide nitrogen substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.44 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 8.08 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.03 |
| CHEMBL5594274 | — | — | 1 | 7.91 |
| CHEMBL5593374 | — | — | 1 | 7.83 |
| CHEMBL5593031 | — | — | 1 | 7.83 |
| CHEMBL5589801 | — | — | 1 | 7.53 |
| CHEMBL5591933 | — | — | 1 | 7.48 |
| CHEMBL5595105 | — | — | 1 | 7.46 |
| CHEMBL5589943 | — | — | 1 | 7.17 |
| CHEMBL5583620 | — | — | 1 | 7.16 |
| CHEMBL5594310 | — | — | 1 | 7.15 |
| CHEMBL5593749 | — | — | 1 | 7.14 |
| CHEMBL5595113 | — | — | 1 | 6.84 |
| CHEMBL5591012 | — | — | 1 | 6.55 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL5594274 | — | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL5593374 | — | IC50 | = | 14.8 | nM | 7.83 |
| CHEMBL5593031 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL5589801 | — | IC50 | = | 29.6 | nM | 7.53 |
| CHEMBL5591933 | — | IC50 | = | 32.9 | nM | 7.48 |
| CHEMBL5595105 | — | IC50 | = | 34.4 | nM | 7.46 |
| CHEMBL5589943 | — | IC50 | = | 67.6 | nM | 7.17 |
| CHEMBL5583620 | — | IC50 | = | 69.5 | nM | 7.16 |
| CHEMBL5594310 | — | IC50 | = | 70.8 | nM | 7.15 |
| CHEMBL5593749 | — | IC50 | = | 72.9 | nM | 7.14 |
| CHEMBL5595113 | — | IC50 | = | 145.1 | nM | 6.84 |
| CHEMBL5591012 | — | IC50 | = | 283.8 | nM | 6.55 |
| CHEMBL107 | COLCHICINE | IC50 | - | — | - |