Assay Detail
Binding
CHEMBL5581868
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Inhibition of HIF-2alpha (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Endothelial PAS domain-containing protein 1 (CHEMBL1744522) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent progress in the development of hypoxia-inducible factor 2α (HIF-2α) modulators: Inhibitors, agonists, and degraders (2009-2024).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.19 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5590666 | — | — | 1 | 8.70 |
| CHEMBL5591431 | — | — | 1 | 7.96 |
| CHEMBL5590686 | — | — | 1 | 7.68 |
| CHEMBL5591668 | — | — | 1 | 7.54 |
| CHEMBL5593441 | — | — | 1 | 6.47 |
| CHEMBL5589682 | — | — | 1 | 6.30 |
| CHEMBL5595886 | — | — | 1 | 5.66 |
| CHEMBL5593792 | — | — | 1 | - |
| CHEMBL5593516 | — | — | 1 | - |
| CHEMBL5593428 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5590666 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5591431 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5590686 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5591668 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5593441 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5589682 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5595886 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5593792 | — | EC50 | < | 50.0 | nM | - |
| CHEMBL5593516 | — | EC50 | < | 100.0 | nM | - |
| CHEMBL5593428 | — | EC50 | < | 100.0 | nM | - |