Assay Detail
Binding
CHEMBL5581928
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Inhibition of G9a (unknown origin) by AlphaLISA assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-lysine N-methyltransferase EHMT2 (CHEMBL6032) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Highly Potent Lysine Methyltransferases G9a/NSD2 Dual Inhibitor to Treat Solid Tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.81 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5207914 | — | — | 1 | 8.07 |
| CHEMBL5591832 | — | — | 1 | 7.50 |
| CHEMBL5592107 | — | — | 1 | 7.44 |
| CHEMBL5590338 | — | — | 1 | 7.35 |
| CHEMBL5592239 | — | — | 1 | 7.32 |
| CHEMBL5591500 | — | — | 1 | 7.27 |
| CHEMBL5592600 | — | — | 1 | 7.19 |
| CHEMBL5590208 | — | — | 1 | 7.18 |
| CHEMBL5583700 | — | — | 1 | 7.07 |
| CHEMBL5170450 | — | — | 1 | 7.00 |
| CHEMBL1232453 | — | — | 1 | 6.80 |
| CHEMBL5595949 | — | — | 1 | 6.78 |
| CHEMBL5594410 | — | — | 1 | 6.70 |
| CHEMBL5593211 | — | — | 1 | 6.70 |
| CHEMBL5591131 | — | — | 1 | 6.62 |
| CHEMBL5591835 | — | — | 1 | 6.51 |
| CHEMBL5595912 | — | — | 1 | 6.48 |
| CHEMBL5593275 | — | — | 1 | 6.46 |
| CHEMBL5592280 | — | — | 1 | 6.05 |
| CHEMBL5592452 | — | — | 1 | 5.95 |
| CHEMBL5592412 | — | — | 1 | 5.89 |
| CHEMBL5592774 | — | — | 1 | 5.54 |
| CHEMBL5593832 | — | — | 1 | - |
| CHEMBL5589842 | — | — | 1 | - |
| CHEMBL2441082 | — | — | 1 | - |
| CHEMBL5589782 | — | — | 1 | - |
| CHEMBL5396252 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5207914 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL5591832 | — | IC50 | = | 31.5 | nM | 7.50 |
| CHEMBL5592107 | — | IC50 | = | 36.5 | nM | 7.44 |
| CHEMBL5590338 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5592239 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL5591500 | — | IC50 | = | 53.5 | nM | 7.27 |
| CHEMBL5592600 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL5590208 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL5583700 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL5170450 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1232453 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5595949 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL5594410 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL5593211 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5591131 | — | IC50 | = | 241.0 | nM | 6.62 |
| CHEMBL5591835 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5595912 | — | IC50 | = | 334.0 | nM | 6.48 |
| CHEMBL5593275 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL5592280 | — | IC50 | = | 887.0 | nM | 6.05 |
| CHEMBL5592452 | — | IC50 | = | 1131.0 | nM | 5.95 |
| CHEMBL5592412 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL5592774 | — | IC50 | = | 2849.0 | nM | 5.54 |
| CHEMBL5593832 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5589842 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2441082 | — | IC50 | < | 2.5 | nM | - |
| CHEMBL5589782 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5396252 | — | IC50 | < | 100.0 | nM | - |