Assay Detail
Functional
CHEMBL5581931
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 96 hrs by CCK-8 cell viability assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Highly Potent Lysine Methyltransferases G9a/NSD2 Dual Inhibitor to Treat Solid Tumors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.73 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5591131 | — | — | 1 | 6.14 |
| CHEMBL5591835 | — | — | 1 | 6.09 |
| CHEMBL5590338 | — | — | 1 | 5.84 |
| CHEMBL5583700 | — | — | 1 | 5.66 |
| CHEMBL2441082 | — | — | 1 | 5.48 |
| CHEMBL5589842 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5591131 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL5591835 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL5590338 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL5583700 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL2441082 | — | IC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL5589842 | — | IC50 | = | 6500.0 | nM | 5.19 |