Assay Detail
Binding
CHEMBL5581971
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human Avi-tagged MUS81 (246 to 551 residues)/2x8His-tagged EME1 (246 to 570 residues) extracted from Escherichia coli BL21 Gold (DE3) by SPR analysis
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Fragment-Based Discovery of Novel MUS81 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 24 | 5.63 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5595635 | — | — | 1 | 6.37 |
| CHEMBL5595231 | — | — | 1 | 6.27 |
| CHEMBL5592380 | — | — | 1 | 6.17 |
| CHEMBL5188107 | — | — | 1 | 6.14 |
| CHEMBL5594006 | — | — | 1 | 6.10 |
| CHEMBL4226761 | — | — | 1 | 6.00 |
| CHEMBL188448 | — | — | 1 | 5.96 |
| CHEMBL5591377 | — | — | 1 | 5.96 |
| CHEMBL5594391 | — | — | 1 | 5.92 |
| CHEMBL5595627 | — | — | 1 | 5.89 |
| CHEMBL5593401 | — | — | 1 | 5.85 |
| CHEMBL5592602 | — | — | 1 | 5.75 |
| CHEMBL5594260 | — | — | 1 | 5.70 |
| CHEMBL5594490 | — | — | 1 | 5.68 |
| CHEMBL203976 | — | — | 1 | 5.66 |
| CHEMBL440562 | — | — | 1 | 5.64 |
| CHEMBL5594819 | — | — | 1 | 5.40 |
| CHEMBL5592973 | — | — | 1 | 5.37 |
| CHEMBL4225408 | — | — | 1 | 5.32 |
| CHEMBL4174171 | — | — | 1 | 4.36 |
| CHEMBL3617204 | — | — | 1 | 4.25 |
| CHEMBL5584056 | — | — | 1 | 4.13 |
| CHEMBL5595842 | — | — | 1 | - |
| CHEMBL5595830 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5595635 | — | Kd | = | 430.0 | nM | 6.37 |
| CHEMBL5595231 | — | Kd | = | 540.0 | nM | 6.27 |
| CHEMBL5592380 | — | Kd | = | 670.0 | nM | 6.17 |
| CHEMBL5188107 | — | Kd | = | 720.0 | nM | 6.14 |
| CHEMBL5594006 | — | Kd | = | 790.0 | nM | 6.10 |
| CHEMBL4226761 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL188448 | — | Kd | = | 1100.0 | nM | 5.96 |
| CHEMBL5591377 | — | Kd | = | 1100.0 | nM | 5.96 |
| CHEMBL5594391 | — | Kd | = | 1200.0 | nM | 5.92 |
| CHEMBL5595627 | — | Kd | = | 1300.0 | nM | 5.89 |
| CHEMBL5593401 | — | Kd | = | 1400.0 | nM | 5.85 |
| CHEMBL5592602 | — | Kd | = | 1800.0 | nM | 5.75 |
| CHEMBL5594260 | — | Kd | = | 2000.0 | nM | 5.70 |
| CHEMBL5594490 | — | Kd | = | 2100.0 | nM | 5.68 |
| CHEMBL203976 | — | Kd | = | 2200.0 | nM | 5.66 |
| CHEMBL440562 | — | Kd | = | 2300.0 | nM | 5.64 |
| CHEMBL5594819 | — | Kd | = | 4000.0 | nM | 5.40 |
| CHEMBL5592973 | — | Kd | = | 4300.0 | nM | 5.37 |
| CHEMBL4225408 | — | Kd | = | 4800.0 | nM | 5.32 |
| CHEMBL4174171 | — | Kd | = | 44000.0 | nM | 4.36 |
| CHEMBL3617204 | — | Kd | = | 56000.0 | nM | 4.25 |
| CHEMBL5584056 | — | Kd | = | 74000.0 | nM | 4.13 |
| CHEMBL5595842 | — | Kd | > | 100000.0 | nM | - |
| CHEMBL5595830 | — | Kd | > | 100000.0 | nM | - |