Assay Detail
Binding
CHEMBL5582392
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of His-tagged human PP5 extracted from Escherichia coli BL21 using pNPP as substrate assessed as increase in phosphatase activity incubated for 30 mins by spectrophotometric analysis
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein phosphatase 5 (CHEMBL3425389) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Allosteric Activation of Protein Phosphatase 5 with Small Molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 2 | - | - |
| EC50 | 1 | 4.28 | 4.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5593159 | — | — | 1 | 4.28 |
| CHEMBL2004669 | — | — | 1 | - |
| CHEMBL5591995 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5593159 | — | EC50 | = | 52800.0 | nM | 4.28 |
| CHEMBL2004669 | — | Activity | - | — | - | |
| CHEMBL5591995 | — | Activity | - | — | - |