Assay Detail
Binding
CHEMBL5582424
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human PP5 extracted from Escherichia coli BL21 using immobilized CDC37 as substrate assessed as increase in PP5 binding to substrate by measuring dissociation constant preincubated with compound for 10 mins followed by CDC37 addition by biolayer interferometric analysis (Rvb = 20.9 nM )
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein phosphatase 5 (CHEMBL3425389) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Allosteric Activation of Protein Phosphatase 5 with Small Molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 1 | 9.27 | 9.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5593159 | — | — | 1 | 9.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5593159 | — | Kd | = | 0.54 | nM | 9.27 |