Assay Detail
Functional
CHEMBL5582728
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Inhibition of cell proliferation in human KARPAS-422 cells incubated for 72 hrs by CellTiter-Glo luminescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KARPAS-422 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A Mitochondria-Targeting SIRT3 Inhibitor with Activity against Diffuse Large B Cell Lymphoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.23 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5595804 | — | — | 1 | 6.19 |
| CHEMBL5593038 | — | — | 1 | 5.70 |
| CHEMBL5594018 | — | — | 1 | 4.73 |
| CHEMBL5594863 | — | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5595804 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL5593038 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL5594018 | — | IC50 | = | 18710.0 | nM | 4.73 |
| CHEMBL5594863 | — | IC50 | = | 51950.0 | nM | 4.28 |