Assay Detail
Binding
CHEMBL5582937
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of eEF2K (unknown origin) measured after 30 mins of incubation
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Eukaryotic elongation factor 2 kinase (CHEMBL5026) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Activity Relationship Studies of Substituted 2-Phenyl-1,2,4-triazine-3,5(2<i>H</i>,4<i>H</i>)-dione Analogues: Development of Potent eEF2K Degraders against Triple-Negative Breast Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.55 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1977874 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1977874 | — | IC50 | = | 280.0 | nM | 6.55 |