Assay Detail
Functional
CHEMBL5582994
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Antiproliferative activity against human A2780T cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780/Taxol |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A Comparative Study on the DNA Interactions and Biological Activities of Benzophenanthridine and Protoberberine Alkaloids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.40 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417799 | SANGUINARIUM | 2.0 | 1 | 6.40 |
| CHEMBL13045 | CHELERYTHRINE | — | 1 | 6.40 |
| CHEMBL176008 | NITIDINE | — | 1 | 6.40 |
| CHEMBL5593587 | — | — | 1 | 6.40 |
| CHEMBL5594821 | — | — | 1 | - |
| CHEMBL295124 | BERBERINE | 4.0 | 1 | - |
| CHEMBL362071 | COPTISINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417799 | SANGUINARIUM | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL13045 | CHELERYTHRINE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL176008 | NITIDINE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5593587 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5594821 | — | IC50 | >= | 24330.0 | nM | - |
| CHEMBL295124 | BERBERINE | IC50 | >= | 24330.0 | nM | - |
| CHEMBL362071 | COPTISINE | IC50 | >= | 24330.0 | nM | - |