Assay Detail
Functional
CHEMBL5583148
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against VEEV expressing TC83-nLuc-nsP3 infected in human MRC5 cells assessed as reduction in viral replication preincubated with cells for 1 hr followed by viral infection and measured after 6 hrs post infection by Nano-glo luciferase assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Venezuelan equine encephalitis virus |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Venezuelan equine encephalitis virus (CHEMBL613726) ↗| Type | ORGANISM |
| Organism | Venezuelan equine encephalitis virus |
Publication
Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of <i>Chikungunya</i> nsP2 Cysteine Protease with Antialphavirus Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 6.52 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5594644 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5594644 | — | EC50 | = | 300.0 | nM | 6.52 |