Assay Detail
Binding
CHEMBL5583272
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NLRP3 in PMA-differentiated human THP-1 cells assessed as inhibition of LPS/nigericin induced IL-1beta production by ELISA
55
Total Activities
55
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NACHT, LRR and PYD domains-containing protein 3 (CHEMBL1741208) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, Synthesis, and Bioevaluation of Novel NLRP3 Inhibitor with IBD Immunotherapy from the Virtual Screen.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 55 | 5.62 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3183703 | — | — | 1 | 7.92 |
| CHEMBL5591066 | — | — | 1 | 6.58 |
| CHEMBL5591726 | — | — | 1 | 6.37 |
| CHEMBL5590770 | — | — | 1 | 6.17 |
| CHEMBL5590073 | — | — | 1 | 6.15 |
| CHEMBL5595030 | — | — | 1 | 6.09 |
| CHEMBL5590187 | — | — | 1 | 6.02 |
| CHEMBL5592068 | — | — | 1 | 5.99 |
| CHEMBL5596006 | — | — | 1 | 5.97 |
| CHEMBL5592969 | — | — | 1 | 5.73 |
| CHEMBL5593521 | — | — | 1 | 5.39 |
| CHEMBL5595876 | — | — | 1 | 5.37 |
| CHEMBL5595046 | — | — | 1 | 5.36 |
| CHEMBL5595175 | — | — | 1 | 5.36 |
| CHEMBL5592483 | — | — | 1 | 5.30 |
| CHEMBL5591774 | — | — | 1 | 5.29 |
| CHEMBL5592212 | — | — | 1 | 5.16 |
| CHEMBL5595491 | — | — | 1 | 5.14 |
| CHEMBL5593090 | — | — | 1 | 5.12 |
| CHEMBL5594085 | — | — | 1 | 5.10 |
| CHEMBL5593101 | — | — | 1 | 5.01 |
| CHEMBL5593950 | — | — | 1 | 5.00 |
| CHEMBL5592009 | — | — | 1 | 4.76 |
| CHEMBL62044 | — | — | 1 | 4.56 |
| CHEMBL5583769 | — | — | 1 | - |
| CHEMBL5591264 | — | — | 1 | - |
| CHEMBL5591334 | — | — | 1 | - |
| CHEMBL5591402 | — | — | 1 | - |
| CHEMBL5595603 | — | — | 1 | - |
| CHEMBL5593191 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3183703 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5591066 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5591726 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5590770 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL5590073 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL5595030 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL5590187 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL5592068 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL5596006 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL5592969 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL5593521 | — | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL5595876 | — | IC50 | = | 4310.0 | nM | 5.37 |
| CHEMBL5595046 | — | IC50 | = | 4340.0 | nM | 5.36 |
| CHEMBL5595175 | — | IC50 | = | 4420.0 | nM | 5.36 |
| CHEMBL5592483 | — | IC50 | = | 5030.0 | nM | 5.30 |
| CHEMBL5591774 | — | IC50 | = | 5190.0 | nM | 5.29 |
| CHEMBL5592212 | — | IC50 | = | 6930.0 | nM | 5.16 |
| CHEMBL5595491 | — | IC50 | = | 7310.0 | nM | 5.14 |
| CHEMBL5593090 | — | IC50 | = | 7670.0 | nM | 5.12 |
| CHEMBL5594085 | — | IC50 | = | 7880.0 | nM | 5.10 |
| CHEMBL5593101 | — | IC50 | = | 9740.0 | nM | 5.01 |
| CHEMBL5593950 | — | IC50 | = | 9890.0 | nM | 5.00 |
| CHEMBL5592009 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL62044 | — | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL5595666 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5590194 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5594368 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5592767 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5594957 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5592777 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5583735 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5592142 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5593730 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5594303 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5591887 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5593527 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5592332 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5593637 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5595419 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5592662 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5589977 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5589633 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5593889 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5594976 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5593191 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5595603 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5591402 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5591334 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5591264 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5583769 | — | IC50 | > | 10000.0 | nM | - |