Assay Detail
Functional
CHEMBL5584423
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Antiproliferative activity against human K562 cells by CCK8 assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of sinomenine/8-Bis(benzylthio)octanoic acid hybrids as potential anti-leukemia drug candidate via mitochondrial pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.82 | 5.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5596781 | — | — | 1 | 5.61 |
| CHEMBL5597038 | — | — | 1 | 5.52 |
| CHEMBL5597116 | — | — | 1 | 5.38 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.29 |
| CHEMBL5597728 | — | — | 1 | 5.27 |
| CHEMBL5596889 | — | — | 1 | 4.77 |
| CHEMBL5596972 | — | — | 1 | 4.76 |
| CHEMBL5598228 | — | — | 1 | 4.75 |
| CHEMBL5597019 | — | — | 1 | 4.72 |
| CHEMBL5596952 | — | — | 1 | 4.71 |
| CHEMBL5598043 | — | — | 1 | 4.67 |
| CHEMBL5597284 | — | — | 1 | 4.65 |
| CHEMBL5597370 | — | — | 1 | 4.63 |
| CHEMBL5597832 | — | — | 1 | 4.62 |
| CHEMBL5597192 | — | — | 1 | 4.60 |
| CHEMBL5596120 | — | — | 1 | 4.58 |
| CHEMBL5596546 | — | — | 1 | 4.56 |
| CHEMBL5596803 | — | — | 1 | 4.48 |
| CHEMBL248095 | SINOMENINE | 3.0 | 1 | 4.43 |
| CHEMBL5598391 | — | — | 1 | 4.41 |
| CHEMBL5597524 | — | — | 1 | - |
| CHEMBL3186849 | CPI 613 | 3.0 | 1 | - |
| CHEMBL5597630 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5596781 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL5597038 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL5597116 | — | IC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 5180.0 | nM | 5.29 |
| CHEMBL5597728 | — | IC50 | = | 5320.0 | nM | 5.27 |
| CHEMBL5596889 | — | IC50 | = | 16830.0 | nM | 4.77 |
| CHEMBL5596972 | — | IC50 | = | 17420.0 | nM | 4.76 |
| CHEMBL5598228 | — | IC50 | = | 17760.0 | nM | 4.75 |
| CHEMBL5597019 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL5596952 | — | IC50 | = | 19460.0 | nM | 4.71 |
| CHEMBL5598043 | — | IC50 | = | 21540.0 | nM | 4.67 |
| CHEMBL5597284 | — | IC50 | = | 22540.0 | nM | 4.65 |
| CHEMBL5597370 | — | IC50 | = | 23370.0 | nM | 4.63 |
| CHEMBL5597832 | — | IC50 | = | 24270.0 | nM | 4.62 |
| CHEMBL5597192 | — | IC50 | = | 25120.0 | nM | 4.60 |
| CHEMBL5596120 | — | IC50 | = | 26030.0 | nM | 4.58 |
| CHEMBL5596546 | — | IC50 | = | 27450.0 | nM | 4.56 |
| CHEMBL5596803 | — | IC50 | = | 32980.0 | nM | 4.48 |
| CHEMBL248095 | SINOMENINE | IC50 | = | 37240.0 | nM | 4.43 |
| CHEMBL5598391 | — | IC50 | = | 39320.0 | nM | 4.41 |
| CHEMBL5597524 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL3186849 | CPI 613 | IC50 | > | 50000.0 | nM | - |
| CHEMBL5597630 | — | IC50 | = | 158000.0 | nM | - |