Assay Detail
Binding
CHEMBL5584451
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Inhibition of GBA (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid derivative as a potent and selective heparanase-1 inhibitor utilizing an improved synthetic approach.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.56 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5404984 | — | — | 1 | 6.36 |
| CHEMBL5597984 | — | — | 1 | 5.90 |
| CHEMBL5598169 | — | — | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5404984 | — | IC50 | = | 439.0 | nM | 6.36 |
| CHEMBL5597984 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL5598169 | — | IC50 | = | 38600.0 | nM | 4.41 |