Assay Detail
Binding
CHEMBL5584452
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Inhibition of human neutrophil elastase by enzymatic assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of sirtinol analogs as human neutrophil elastase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.89 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76688 | SIVELESTAT | 3.0 | 1 | 7.39 |
| CHEMBL5596128 | — | — | 1 | 5.31 |
| CHEMBL5597970 | — | — | 1 | 4.92 |
| CHEMBL5596366 | — | — | 1 | 4.78 |
| CHEMBL5598528 | — | — | 1 | 4.74 |
| CHEMBL5598246 | — | — | 1 | 4.72 |
| CHEMBL5597074 | — | — | 1 | 4.72 |
| CHEMBL5597807 | — | — | 1 | 4.69 |
| CHEMBL5590556 | — | — | 1 | 4.68 |
| CHEMBL5596269 | — | — | 1 | 4.68 |
| CHEMBL5596378 | — | — | 1 | 4.65 |
| CHEMBL380797 | SIRTINOL | — | 1 | 4.61 |
| CHEMBL5597675 | — | — | 1 | 4.58 |
| CHEMBL5596130 | — | — | 1 | 4.51 |
| CHEMBL5598272 | — | — | 1 | 4.41 |
| CHEMBL5597733 | — | — | 1 | - |
| CHEMBL5597211 | — | — | 1 | - |
| CHEMBL5596590 | — | — | 1 | - |
| CHEMBL5597683 | — | — | 1 | - |
| CHEMBL5598422 | — | — | 1 | - |
| CHEMBL5596671 | — | — | 1 | - |
| CHEMBL5596498 | — | — | 1 | - |
| CHEMBL5597358 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76688 | SIVELESTAT | IC50 | = | 40.97 | nM | 7.39 |
| CHEMBL5596128 | — | IC50 | = | 4910.0 | nM | 5.31 |
| CHEMBL5597970 | — | IC50 | = | 12070.0 | nM | 4.92 |
| CHEMBL5596366 | — | IC50 | = | 16770.0 | nM | 4.78 |
| CHEMBL5598528 | — | IC50 | = | 18040.0 | nM | 4.74 |
| CHEMBL5598246 | — | IC50 | = | 18950.0 | nM | 4.72 |
| CHEMBL5597074 | — | IC50 | = | 19250.0 | nM | 4.72 |
| CHEMBL5597807 | — | IC50 | = | 20360.0 | nM | 4.69 |
| CHEMBL5590556 | — | IC50 | = | 20660.0 | nM | 4.68 |
| CHEMBL5596269 | — | IC50 | = | 21030.0 | nM | 4.68 |
| CHEMBL5596378 | — | IC50 | = | 22440.0 | nM | 4.65 |
| CHEMBL380797 | SIRTINOL | IC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL5597675 | — | IC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL5596130 | — | IC50 | = | 31220.0 | nM | 4.51 |
| CHEMBL5598272 | — | IC50 | = | 38810.0 | nM | 4.41 |
| CHEMBL5597733 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5597211 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5596590 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5597683 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5598422 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5596671 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5596498 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5597358 | — | IC50 | > | 50000.0 | nM | - |